Product Name :
p57 Kip2 Recombinant Rabbit Monoclonal Antibody [JE02-08]
Predicted band size :
32 kDa
Observed band size :
50 kDa
Synonyms:
Beckwith Wiedemann syndrome antibody BWCR antibody BWS antibody CDKI antibody CDKN 1C antibody CDKN1C antibody CDN1C_HUMAN antibody Cyclin dependent kinase inhibitor 1C antibody Cyclin dependent kinase inhibitor p57 antibody Cyclin-dependent kinase inhibitor 1C antibody 展开
Function :
Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndrome suggesting that it is a tumor suppressor candidate. CDKN1C is a tumor suppressor human gene on chromosome 11 (11p15) and belongs to the cip/kip gene family. It encodes a cell cycle inhibitor that binds to G1 cyclin-CDK complexes. Thus p57KIP2 causes arrest of the cell cycle in G1 phase. CDKN1C was found to lead to cancer cell dormancy; its gene expression is regulated through the activity of glucocorticoid receptors (GRs) through chromatin remodelling mediated by SWI/SNF.BuyMethyl 2-(4-aminophenyl)propanoate
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human p57 Kip2 aa 31-80 / 316.2-Chloro-3-nitrobenzenesulfonyl chloride web
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IHC-P
Coupling :
unconjugated
Clone number:
JE02-08
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33653190 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 32 kDa
Positive control :
HeLa cell lysate, HeLa treated with 50nM dexamethasone for 16 hours cell lysate, SH-SY5Y cell lysate, K-562 cell lysate, 293T cell lysate, Mouse brain tissue lysate, Rat brain tissue lysate, HeLa cells treated with 50nM dexamethasone for 16 hours, human placenta tissue, human brain tissue, mouse brain tissue, rat brain tissue.