Vest 2012, 122:3063?087. 38. Sargsyan SA, Blackburn DJ, Barber SC, Monk PN, Shaw PJ: Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1. NeuroReport 2009, 20:1450?455. 39. Semple BD, Kossmann T, Morganti-Kossmann MC: Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks. J Cereb Blood Flow Metab 2010, 30:459?73. 40. Croitoru-Lamoury J, Guillemin GJ, Boussin FD, Mognetti B, Gigout LI, Ch et A, Vaslin B, Le Grand R, Brew BJ, Dormont D: Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF and IFN in CXCR4 and CCR5 modulation. Glia 2003, 41:354?70. 41. Hickman SE, El Khoury J: Mechanisms of mononuclear phagocyte recruitment in Alzheimer’s illness. CNS Neurol Disord Drug Targets 2010, 9:168?73. 42. Tanuma N, Sakuma H, Sasaki A, Matsumoto Y: Chemokine expression by astrocytes plays a part in microglia/macrophage activation and subsequent neurodegeneration in secondary progressive multiple sclerosis. Acta Neuropathol 2006, 112:195?04. 43. Jee Y, Yoon WK, Okura Y, Tanuma N, Matsumoto Y: Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 within the central nervous system is closely linked to relapse of autoimmune encephalomyelitis in Lewis rats. J Neuroimmunol 2002, 128:49?7. 44. Quinones MP, Kalkonde Y, Estrada CA, Jimenez F, Ramirez R, Mahimainathan L, et al: Part of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals market astrocyte activation and survival by means of NF-kappaB and Akt. Mol Cell Neurosci 2008, 37:96?09. 45. Andjelkovic AV, Song L, Dzenko KA, Cong H, Pachter JS: Functional expression of CCR2 by human fetal astrocytes. J Neurosci Res 2002, 70:219?31. 46. Sofroniew MV, Vinters HV: Astrocytes: biology and pathology. Acta Neuropathol 2010, 119:7?5. 47. Xia MQ, Hyman BT: Chemokines/chemokine receptors inside the central nervous system and Alzheimer’s disease. J Neurovirol 1999, five:32?1. 48. Rappold PM, Tieu K: Astrocytes and therapeutics for Parkinson’s disease. Neurotherapeutics 2010, 7:413?23. 49. Ferraiuolo L, Higginbottom A, Heath PR, Barber S, Greenald D, Kirby J, Shaw PJ: Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain 2011, 134:2627?641. 50. Papadeas ST, Kraig SE, O’Banion C, Lepore AC, Maragakis NJ: Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wildtype motor neuron degeneration in vivo. Proc Natl Acad Sci USA 2011, 108:17803?7808. 51. van Der Voorn P, Tekstra J, Beelen RH, Tensen CP, Van Der Valk P, De Groot CJ: Expression of MCP-1 by reactive astrocytes in demyelinating various sclerosis lesions.BuyLauroyl-L-carnitine (chloride) Am J Pathol 1999, 154:45?1.165894-07-5 Chemical name 52.PMID:33508970 Takano T, Oberheim N, Cotrina ML, Nedergaard M: Astrocytes and ischemic injury. Stroke 2009, 40:S8?two.Kawaguchi-Niida et al. Acta Neuropathologica Communications 2013, 1:21 http://actaneurocomms.org/content/1/1/Page 12 of53. Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Takahashi R, Misawa H, Cleaveland DW: Astrocytes as determinants of illness progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 2008, 11:251?53. 54. Jayapal KP, Philp RJ, Kok YJ, Yap MG, Sherman DH, Griffin TJ, Hu WS: Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. PLoS A single 2008, three:e2097. 55. Kabashi E, Durham HD: Failure of protein high-quality.