Product Name :
3-Anilino-2-(3,4,5-Trimethoxybenzyl)acrylonitrile (CAS 30078-48-9)
Synonym :
Trimethoprim Impurity I
Application :
CAS:
30078-48-9
Purity:
≥98%
Molecular Weight:
324.37
Formula :
C19H20N2O3
Physical state:
Solid
solubility :
Soluble in acetone, chloroform, Dichloromethane, Warm Ethanol, methanol, and Toluene.
Shipping Condition :
Store at 4° C
Melting point:
>123° C (dec.)
SMILES:
COC1=CC(=CC(=C1OC)OC)CC(=CNC2=CC=CC=C2)C#N
References:
:Isolation and identification of process impurities in trimethoprim drug substance by high-performance liquid chromatography, atmospheric pressure chemical ionization liquid chromatography/mass spectrometry and nuclear magnetic resonance spectroscopy.24666-56-6 Description | Lehr, GJ.1240594-41-5 chemscene , et al.PMID:33393881 1999. J Pharm Biomed Anal. 19: 373-89. PMID: 10704103Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes. | Goldman, JL., et al. 2016. Drug Metab Dispos. 44: 1603-7. PMID: 27457783Quantitative NMR (qNMR) for pharmaceutical analysis: The pioneering work of George Hanna at the US FDA. | Jaki, BU., et al. 2021. Magn Reson Chem. 59: 7-15. PMID: 32910504