Product Name :
3-Bromopyruvic acid (CAS 1113-59-3)
Synonym :
3-Bromopyruvic acid is also known as 3-Bromo-2-oxopropionic acid.
Application :
3-Bromopyruvic acid is a cross-linker between nucleic acids and proteins, and is also an affinity label for cysteine residues.
CAS:
1113-59-3
Purity:
≥97%
Molecular Weight:
166.96
Formula :
C3H3BrO3
Physical state:
Solid
solubility :
Soluble in water (100 mg/ml), DMSO, ethyl acetate, and water.
Shipping Condition :
Store at 4° C
Melting point:
77-82° C
SMILES:
C(C(=O)C(=O)O)Br
References:
:3-BROMOPYRUVIC ACID, A HIGHLY SELECTIVE ANTIMICROBIAL AGENT AGAINST CERTAIN YEASTS. | ZYGMUNT, WA. and MARTIN, TA. 1964. J Pharm Sci. 53: 1420-1. PMID: 14253613Inhibitive effect of 3-bromopyruvic acid on human breast cancer MCF-7 cells involves cell cycle arrest and apoptotic induction. | Liu, XH., et al. 2009. Chin Med J (Engl). 122: 1681-5. PMID: 19719971Effect of 3-bromopyruvic acid on human erythrocyte antioxidant defense system. | Sadowska-Bartosz, I. and Bartosz, G. 2013. Cell Biol Int. 37: 1285-90. PMID: 238818493-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings. | Gong, L., et al. 2014. Anticancer Agents Med Chem. 14: 771-6. PMID: 24738957Limitations of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay when compared to three commonly used cell enumeration assays. | van Tonder, A., et al. 2015. BMC Res Notes. 8: 47. PMID: 25884200Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. | Garcia-Carbonell, R., et al. 2016. Arthritis Rheumatol. 68: 1614-26. PMID: 26815411Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione. | Sadowska-Bartosz, I., et al.27913-58-2 manufacturer 2016.5337-93-9 supplier Pharmacol Rep.PMID:33615661 68: 502-5. PMID: 269225603-Bromopyruvic Acid Inhibits Tricarboxylic Acid Cycle and Glutaminolysis in HepG2 Cells. | Jardim-Messeder, D. and Moreira-Pacheco, F. 2016. Anticancer Res. 36: 2233-41. PMID: 27127128ABCB1-overexpressing MDCK-II cells are hypersensitive to 3-bromopyruvic acid. | Sadowska-Bartosz, I., et al. 2016. Life Sci. 162: 138-44. PMID: 275349093-Bromopyruvate induces expression of antioxidant genes. | Pulaski, L., et al. 2019. Free Radic Res. 53: 170-178. PMID: 30362385Electron-Induced Reactions in 3-Bromopyruvic Acid. | Ferreira da Silva, F., et al. 2019. Chemistry. 25: 5498-5506. PMID: 30706547Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson′s disease. | Li, J., et al. 2022. Neurobiol Dis. 163: 105605. PMID: 34973450Novel insights into the anti-cancer effects of 3-bromopyruvic acid against castration-resistant prostate cancer. | Yeh, HC., et al. 2022. Eur J Pharmacol. 923: 174929. PMID: 353640713-Bromopyruvic acid regulates glucose metabolism by targeting the c-Myc/TXNIP axis and induces mitochondria-mediated apoptosis in TNBC cells. | Li, J., et al. 2022. Exp Ther Med. 24: 520. PMID: 35837063Data on the combined effect of atovaquone, mefloquine, and 3-bromopyruvic acid against Echinococcus multilocularis protoscoleces. | Kouguchi, H., et al. 2022. Data Brief. 45: 108707. PMID: 36426011