Product Name :
PAX8 Recombinant Rabbit Monoclonal Antibody [JE80-01]
Predicted band size :
48 kDa
Observed band size :
48 kDa
Synonyms:
OTTHUMP00000158659 antibody OTTHUMP00000158660 antibody OTTHUMP00000203723 antibody OTTHUMP00000203724 antibody Paired box 8 antibody Paired box gene 8 antibody paired box homeotic gene 8 antibody Paired box protein Pax 8 antibody Paired box protein Pax-8 antibody Paired domain gene 8 antibody 展开
Function :
PAX8 is a transcription factor crucial to the organogenesis and development of the thyroid gland, urogenital tract, placenta and inner ear. In the thyroid, PAX8 is a master gene that regulates maintenance of the differentiated thyroid follicular cell phenotype, where it controls and activates the transcription of the main proteins responsible for the functional activity of follicular cells such as thyroglobulin, thyroperoxidase and sodium/iodide symporter. In the developing kidney PAX8 is important for renal vescicle formation. PAX8 regulates the expression of the WT1 gene. PAX8 appears to be currently the most sensitive and specific marker for renal cell carcinoma and ovarian non-mucinous carcinoma. Nuclear transcriptional regulator in the paired-box family expressed during organogenesis of the thyroid gland, kidney, and Müllerian tract. Chromosomal localization 2q13, Molecular weight of the unprocessed precursor 48 kDa, of five isoforms 31-42 kDa.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within Human PAX8 aa 120-450.
Species reactivity:
Human, Mouse
Verify application:
WB, IHC-P, IF-Cell
Coupling :
unconjugated
Clone number:
JE80-01
RRID:
AB_3072051
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.5-Fluoro-2-iodobenzoic acid methyl ester In stock
Storage buffer solution:
1*TBS (pH7.1207625-15-7 structure 4), 0.PMID:33538985 05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 48 kDa
Positive control :
NIH: OVCAR-3 cell lysates, SKOV-3 cell lysates, SKOV-3, human thyroid tissue, human kidney tissue, human thyroid carcinoma tissue, human ovary carcinoma tissue, human renal clear cell carcinoma tissue, mouse thyroid tissue, mouse kidney tissue, rat kidney tissue.